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Derivative of diclofenac, created to provide similar pain-relieving and anti-inflammatory benefits but with better gastrointestinal tolerability.
proteolytic enzyme originally isolated from Serratia marcescens bacteria in the intestine of silkworms.
Developed: Early 1990s
Origin: A derivative of diclofenac, created to provide similar pain-relieving and anti-inflammatory benefits but with better gastrointestinal tolerability.
Purpose: Designed as a safer NSAID alternative for long-term use in arthritis.
Approval: Became widely used in Europe and Asia for conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Discovered: 1877
Introduced to medicine: 1950s
Origin: Derived from earlier analgesics (acetanilide, phenacetin).
Reason for popularity:
Effective for pain and fever
Safer than aspirin for the stomach
Current status: One of the most widely used painkillers worldwide.
Discovered: 1960s in Japan
Source: A proteolytic enzyme originally isolated from Serratia marcescens bacteria in the intestine of silkworms.
Purpose:
Reduces inflammation
Helps break down inflammatory proteins
Reduces swelling and promotes healing
Widely used in India, Japan, and parts of Europe for postoperative swelling and musculoskeletal inflammation.
By the early 2000s, pharmaceutical companies began combining:
NSAID (aceclofenac)
Analgesic/antipyretic (paracetamol)
Anti-inflammatory enzyme (serratiopeptidase)
Purpose: create a multi-mechanism pain reliever for faster relief in:
muscle pain
joint pain
post-injury swelling
postoperative inflammation
Sustained-release (SR) versions like Zuno-SR came later to provide longer-lasting pain control with fewer doses.
Zuno-SR is a modern formulation, but its ingredients have decades of medical history:
Paracetamol – 145+ years
Serratiopeptidase – ~60 years
Aceclofenac – ~30 years
Together they form a widely used combination for pain, inflammation, and swelling.
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